Prevalence, clinical characteristics, and prognosis of GATA2-related myelodysplastic syndromes in children and adolescents
This study identifies GATA2 mutations as the most common germline defect predisposing to pediatric MDS with a very high prevalence in adolescents with monosomy 7. GATA2 mutations do not confer poor prognosis in childhood MDS. However, the high risk for progression to advanced disease must guide decision-making toward timely HSCT.
Source: Blood - Category: Hematology Authors: Wlodarski, M. W., Hirabayashi, S., Pastor, V., Stary, J., Hasle, H., Masetti, R., Dworzak, M., Schmugge, M., van den Heuvel-Eibrink, M., Ussowicz, M., De Moerloose, B., Catala, A., Smith, O. P., Sedlacek, P., Lankester, A. C., Zecca, M., Bordon, V., Matth Tags: Pediatric Hematology, Plenary Papers, Free Research Articles, Myeloid Neoplasia, CME article Source Type: research
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