Sphingosine-1-phosphate reduces ischaemia-reperfusion injury by phosphorylating the gap junction protein Connexin43

Conclusion
Our study reveals an important molecular pathway by which modulating the apoM/S1P axis has a therapeutic potential in the fight against I/R injury in the heart.

Source: Cardiovascular Research - February 12, 2016 Category: Cardiology Authors: Morel, S., Christoffersen, C., Axelsen, L. N., Montecucco, F., Rochemont, V., Frias, M. A., Mach, F., James, R. W., Naus, C. C., Chanson, M., Lampe, P. D., Nielsen, M. S., Nielsen, L. B., Kwak, B. R. Tags: Cardiac biology and remodelling Source Type: research