Calmodulin disruption impacts growth and motility in juvenile liver fluke

Conclusions: These data indicate that the Ca 2+ -modulating functions of FhCaMs are important for juvenile fluke growth and movement and provide the first functional genomics-based example of a growth-defect resulting from gene silencing in liver fluke. Whilst the phenotypic impacts of FhCaM silencing on fluke behaviour do not strongly support their candidature as new flukicide targets, the growth impacts encourage further consideration, especially in light of the speed of juvenile fluke growth in vivo.
Source: Parasites and Vectors - Category: Microbiology Authors: Source Type: research