Chronic Co-Administration of Sepiapterin and L-Citrulline Ameliorates Diabetic Cardiomyopathy and Myocardial Ischemia/Reperfusion Injury in Obese Type 2 Diabetic Mice [Original Articles]

Conclusions— Co-administration of SEP and l-Cit limits diabetic cardiomyopathy and ischemia/reperfusion injury in db/db mice through a tetrahydrobiopterin/endothelial nitric oxide synthase/nitric oxide pathway.

http://circheartfailure.ahajournals.org/cgi/content/short/9/1/e002424?rss=1

Source: Circulation: Heart Failure - January 13, 2016 Category: Cardiology Authors: Baumgardt, S. L., Paterson, M., Leucker, T. M., Fang, J., Zhang, D. X., Bosnjak, Z. J., Warltier, D. C., Kersten, J. R., Ge, Z.-D. Tags: Animal Models of Human Disease, Endothelium/Vascular Type/Nitric Oxide, Diabetes, Type 2, Myocardial Infarction, Echocardiography Original Articles Source Type: research