Melanin-concentrating hormone projections to the dorsal raphe nucleus: An immunofluorescence and in vivo microdialysis study

Publication date: March 2016 Source:Journal of Chemical Neuroanatomy, Volume 72 Author(s): Jessika Urbanavicius, Patricia Lagos, Pablo Torterolo, Juan A. Abin-Carriquiry, Cecilia Scorza Melanin-concentrating hormone (MCH)-containing neurons are localized in the lateral hypothalamus and incerto-hypothalamic areas, and project to several brain regions including the dorsal raphe nucleus (DRN). The MCHergic system has been involved in the regulation of emotional states and we have demonstrated that MCH microinjections into the rat DRN promote a depressive-like state. To understand the MCHergic transmission into the DRN, in the present study we characterized the distribution and density of the MCHergic fibers along the rostro-caudal axis of the rat DRN and their anatomical relationship with the 5-HT- and GABA-containing neurons. Additionally, a functional in vivo microdialysis study was carried out in order to evaluate the MCH effects on the 5-HT extracellular levels. Immunolabeling studies showed that MCHergic fibers were widely distributed throughout the rostro-caudal DRN extent and a reduced density at the most caudal level was observed. Interestingly, MCHergic fibers appeared in close apposition to 5-HT and GABA-containing neurons. Microdialysis studies evidenced an opposite effect of two concentrations of MCH on 5-HT levels: the lower concentration (30μM) produced a significant and long-lasting (up to 120min) decrease while the higher (100μM) induced a slight and...
Source: Journal of Chemical Neuroanatomy - Category: Neuroscience Source Type: research

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Publication date: March–April 2020Source: Journal of Applied Developmental Psychology, Volume 67Author(s): Claudine FoxAbstractThis paper reports a study that adopted age-appropriate terminology to investigate 6–11-year-old children's attitudes towards mental illness (N = 120). The study utilized a semi-structured interview technique and card selection tasks to assess the children's attitudes to individuals diagnosed with different mental illnesses (anorexia nervosa, depression and dementia). Their attitudes were measured in terms of social distance, social functioning, emotional response and trait at...
Source: Journal of Applied Developmental Psychology - Category: Child Development Source Type: research
In January, 2019, seven Aboriginal children died by suicide in Australia. By March, at least 24 young Aboriginal people were reported to have taken their lives, including three children younger than 12 years. 1 Despite Australia's wealth, the health st...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
BACKGROUND: About 40,000 infertile couples visit Tu Du Hospital, Vietnam for consultation and treatment of infertility per year. Depression in infertile female patients not only influences mental wellbeing, but also affects the effectiveness of infertility...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Young Adults Source Type: news
Background: About 84% of the agriculture, fishing, and forestry occupational sector is comprised of farmers. This sector is at high risk for suicide in the United States. Recent disasters and trade upheavals may make farmers and their families more vulnera...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Occupational Issues Source Type: news
PURPOSE OF REVIEW: Bipolar disorder has the highest rate of suicide of all psychiatric conditions and is approximately 20-30 times that of the general population. The purpose of this review is to discuss findings relevant to bipolar disorder and suicide. R...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Research Methods, Surveillance and Codes, Models Source Type: news
The objective of this article is to review the current evidence for these association...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
PURPOSE OF REVIEW: To review and discuss recent advances in evidence-based interventions (EBIs) for youth suicide risk. RECENT FINDINGS: There is a growing body of research on the effectiveness of interventions targeting suicidal ideation and behavior amon...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
OBJECTIVES: To determine the incidence, risk, and timing of mortality (unnatural and natural causes) among youth seen in a pediatric emergency department (ED) for mental health concerns, compared with matched non-mental health ED controls.METHODS: ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
There was nothing quite like the slang used in the early days of the space program. Saying something was “OK” would not do when you could say “A-OK” instead. Saying, “Let’s get moving,” when you’ve been sealed in your spacecraft for hours waiting to launch while Mission Control sorts out technical glitches, was weak tea compared to the “Light this candle!” as an exasperated Al Shepard barked in 1961. And then, too, there was “screw the pooch.” A cleaned-up version of a decidedly coarser term, it meant, in the pilot’s argot, to crash your jet or l...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized climate change newsletter Space Source Type: news
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Source: Archives of Suicide Research - Category: Psychiatry & Psychology Authors: Source Type: research
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