TRPC3 channel confers cerebrovascular remodelling during hypertension via transactivation of EGF receptor signalling

Conclusion
Collectively, we demonstrated that enhanced EGFR transactivation, due to increased TRPC3 expression and functional coupling of TRPC3/ADAM17, resulted in cerebrovascular remodelling. Therefore, TRPC3-induced EGFR transactivation may be therapeutically exploited to prevent hypertension-induced cerebrovascular remodelling.

Source: Cardiovascular Research - December 28, 2015 Category: Cardiology Authors: Wang, M., Tang, Y.-B., Ma, M.-M., Chen, J.-H., Hu, C.-P., Zhao, S.-P., Peng, D.-Q., Zhou, J.-G., Guan, Y.-Y., Zhang, Z. Tags: Integrative physiology and pathophysiology Source Type: research