p53 overexpression increases chemosensitivity in multidrug-resistant osteosarcoma cell lines

Conclusions These results demonstrated that transfection of wild-type p53 increases chemosensitivity either through inhibiting IGF-1r or through increasing the expression of pro-apoptotic proteins p21 and Bax in human MDR osteosarcoma cell lines.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research