Contribution of genome-environment interaction to pre-eclampsia in a Havana Maternity Hospital.

CONCLUSIONS: Familial aggregation of the disorder was demonstrated, the first Cuban epidemiological evidence of genetic and enviromental contributions to pre-eclampsia risk. Familial clustering among the husband's relatives demonstrates the fetal genome's importance in genesis of pre-eclampsia. The interaction of environmental risk factors with genetic ones produces increased pre-eclampsia risk, compared to expectations based on independent action of these variables. KEYWORDS Pre-eclampsia, toxemia of pregnancy, pregnancy outcome, environment, genetics, genome-environment interaction, genetic epidemiology, Cuba. PMID: 23934423 [PubMed - indexed for MEDLINE]
Source: MEDICC Review - Category: Global & Universal Tags: MEDICC Rev Source Type: research