Impaired dopamine D1 receptor-mediated vasorelaxation of mesenteric arteries in obese Zucker rats

Conclusions:
Both hyperinsulinemia and hyperglycemia caused D1 receptor dysfunction by decreasing arterial D1 receptor expression and increasing D1 receptor phosphorylation. Impaired D1 receptor-mediated vasorelaxation is involved in the pathogenesis of obesity-related hypertension.

Source: Cardiovascular Diabetology - February 22, 2014 Category: Cardiology Authors: Jinjuan FuYu HanHongyong WangZhen WangYukai LiuXingjian ChenYue CaiWeiwei GuanDi YangLaureano AsicoLin ZhouPedro JoseChunyu Zeng Source Type: research