LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation

Conclusions
Deletion of LKB1 causes early defects in atrial channel expression, action potential generation and conduction, which precede widespread atrial remodelling, fibrosis and AF. LKB1 is critical for normal atrial growth and electrophysiological function.

Source: Cardiovascular Research - September 16, 2015 Category: Cardiology Authors: Kim, G. E., Ross, J. L., Xie, C., Su, K. N., Zaha, V. G., Wu, X., Palmeri, M., Ashraf, M., Akar, J. G., Russell, K. S., Akar, F. G., Young, L. H. Tags: Ion channels and arrhythmias Source Type: research