Role of the endogenous nitric oxide inhibitor asymmetric dimethylarginine (ADMA) and brain-derived neurotrophic factor (BDNF) in depression and behavioural changes: clinical and preclinical data in chronic kidney disease
Conclusions
Progressive renal failure in rats is accompanied by a marked increase of ADMA and a decrease in BDNF. 5/6 nephrectomy leads to significantly decreased exploratory behaviour and locomotion. Both behaviours could be reproduced by ADMA infusion alone. Indicators of anxiety were more pronounced in ADMA-infused animals when compared with 5/6 nephrectomized rats. Furthermore, an inverse relationship of BDNF and BDI in 11 CKD5D patients was shown.
Source: Nephrology Dialysis Transplantation - Category: Urology & Nephrology Authors: Kielstein, H., Suntharalingam, M., Perthel, R., Song, R., Schneider, S. M., Martens-Lobenhoffer, J., Jager, K., Bode-Boger, S. M., Kielstein, J. T. Tags: Chronic Kidney Disease Source Type: research
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