Biotronik launches 2 new studies

Biotronik announced 2 new studies last week that are slated to examine the company’s CRT-D device and BioMonitor implanted cardiac monitor. A 277-patient BioContinue clinical trial will examine the risk of ventricular arrhythmias after CRT-D replacement, enrolling patients over 2 years at 40 centers across 8 countries, the company said. Biotronik said the trial will be the 1st to investigate defibrillator back-up following device placement in heart failure patients with a primary indication for cardiac resynchronization therapy defibrillators. Patients in the trial will be implanted with Biotronik’s CRT-Ds and assessed for the rate of ventricular tachyarrhythmias over 2 years. Biotronik said that it looks to evaluate the risk of VTA or ventricular fibrillation after replacement, with a primary endpoint being the number of patients with at least one sustained VTA or VF. “Eighty percent of ICD patients implanted for primary prevention do not experience a VTA during the lifetime of their first device. In addition, if these HF patients successfully respond to CRT during their initial device’s lifetime, they may no longer be indicated for defibrillator back-up by the time it is due for replacement. However, even if a patient no longer fulfills the criteria for a defibrillator at the time of CRT-D replacement, the risk of subsequent ventricular arrhythmia could remain. Our goal is to create a risk mapping profile according to individual patient characteristi...
Source: Mass Device - Category: Medical Equipment Authors: Tags: Cardiac Assist Devices Cardiac Implants Cardiovascular Clinical Trials Research & Development Biotronik Source Type: news

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Authors: Samejima Y, Iuchi A, Kanai T, Noda Y, Nasu S, Tanaka A, Morishita N, Suzuki H, Okamoto N, Harada H, Ezumi A, Ueda K, Kawahara K, Hirashima T Abstract Cardiac side effects associated with immune checkpoint inhibitors (ICIs) are an uncommon but serious complication with a relatively high mortality. We experienced a case of cardiomyopathy induced by nivolumab. Echocardiography showed diffuse hypo-kinesis of the left ventricular cardiac wall and a significant decrease in the ejection fraction, like dilated cardiomyopathy. The myocardial biopsy showed non-inflammatory change; cardiac function gradually improved...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Conditions:   Heart Failure;   Crackles;   Heart Failure With Preserved Ejection Fraction Intervention:   Device: Use of Eko CORE and Eko DUO electronic stethoscopes Sponsor:   Eko Devices, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Heart Failure; With Decompensation;   Heart Failureļ¼ŒCongestive;   Heart Failure Acute Intervention:   Device: Telemedicine/telemonitoring (TM) suite Sponsors:   Azienda Ospedaliera Città della Salute e della Scienza di Torino;   Santer Reply S.p.A. Milan, Italy;   Caretek S.r.l. Turin, Italy Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS LC can activate the Nrf2/HO-1 signaling pathway and reduce oxidative stress and apoptosis in cardiomyocytes, thereby reducing myocardial IRI. PMID: 32452468 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Objectives: The study sought to identify the role of Annexin A1 as a congestion marker in acute heart failure, and to identify its putative role in predicting clinical outcomes.Background: Annexin A1 (AnxA1) is a protein that inhibits inflammation following ischemia-reperfusion (I-R) injury in cardiorenal tissues. Since acute heart failure (AHF) is a state of tissue hypoperfusion, we hypothesized that plasma AnxA1 levels are altered in AHF.Methods: In The Renal Optimization Strategies Evaluation (ROSE) trial, patients hospitalized for AHF with kidney injury were randomized to receive dopamine, nesiritide, or placebo for 72...
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Source Type: research
To estimate oxygen uptake (VO2) from cardiopulmonary exercise testing (CPX) using simultaneously recorded seismocardiogram (SCG) and electrocardiogram (ECG) signals captured with a small wearable patch.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Source Type: research
Abstract Caregivers of individuals with heart failure are at high risk for diminished quality of life because of the energy involved in providing necessary care. Caring for someone with chronic heart failure can affect caregivers' physical, psychological, and social health, collectively referred to as the burden of care, and may also affect family functioning. The current cross-sectional study aimed to investigate the relationship between caregiver burden and family functioning in caregivers of older adults with heart failure in southeastern Iran using the Zarit Burden Inventory and the Family Assessment Device ba...
Source: Journal of Gerontological Nursing - Category: Nursing Authors: Tags: J Gerontol Nurs Source Type: research
HEART attacks are strongly tied to unhealthy lifestyle factors and research continues to shed further light on the link between the two. A new study has probed deeper into the relationship, uncovering a risk factor tied to childhood experiences.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Source: BMJ Comments - Category: General Medicine Source Type: forums
Conclusion of first report:In patients with anterior Killip class II or less ST-segment –elevation myocardial infarction undergoing primary percutaneous coronary intervention, early intravenous metoprolol before reperfusion reduced infarct size and increased left ventricular ejection fraction with no excess of adverse events during the first 24 hours after STEMI.Conclusion of 2nd report: In patients with anterior Killip class  ≤II STEMI undergoing pPCI, early IV metoprolol before reperfusion resulted in higher long-term LVEF, reduced incidence of severe LV systolic dysfunction and ICD indications, and fe...
Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
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