Region‐Specific Alterations of Matrix Metalloproteinase Activity in Multiple System Atrophy

ConclusionThese results demonstrate widespread alterations of matrix metalloproteinase expression in MSA and a pattern of increased matrix metalloproteinase‐2 expression and activity affecting preferentially a brain region severely affected (putamen) over a relatively spared region (frontal cortex). Elevated matrix metalloproteinase expression may thus contribute to the disease process in MSA by promoting blood–brain barrier dysfunction and/or myelin degradation. © 2015 International Parkinson and Movement Disorder Society

Source: Movement Disorders - August 1, 2015 Category: Neurology Authors: Fares Bassil, Arnaud Monvoisin, Marie‐Helene Canron, Anne Vital, Wassilios G. Meissner, François Tison, Pierre‐Olivier Fernagut Tags: Research Article Source Type: research