Cleveland Clinic Studies Radiation-induced Mesothelioma

James Stevenson, M.D., renowned oncologist at the Cleveland Clinic, didn't need to see the recent study to know the face of malignant pleural mesothelioma was changing. He sees it in his waiting room all the time. While occupational exposure to asbestos, which is still the No. 1 cause of the rare disease, continues dropping significantly, the rate of mesothelioma remains steady. And the patients don't look the same anymore. Other causes, it seems, are emerging, and they may be rising. "The general thinking is that these non-asbestos related cases will increase as we move forward," said Stevenson, a mesothelioma specialist who brought his expertise to Cleveland in 2012 from the Abramson Cancer Center in Philadelphia. "We all sense there are going to be more of these, even if the hard numbers don't show it yet." Mesothelioma Patients with No Asbestos Exposure Stevenson recently treated two women in their mid-50s, both nonsmokers who had worked in offices with no known asbestos problems. Neither woman was aware of any asbestos in their homes, the homes where they grew up or about any secondhand exposure from parents who could have inadvertently brought asbestos home. "They had no reason to even think they were ever exposed," Stevenson said. All were stunned by a diagnosis of pleural mesothelioma. Mesothelioma specialists across the country often talk about the changing demographics of their patients: They are younger, the percentage of fema...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: Treatment & Doctors Source Type: news

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CONCLUSIONS: This is the first report of the use of lenvatinib for the treatment of distant metastases from CMV-PTC. In addition to the efficacy in treating metastatic lesions of this rare variant of PTC, lenvatinib shows promise in the management of associated FAP. This treatment strategy may be useful in the management of recurrent CMV-PTC and in those with FAP who refuse colectomy. PMID: 31317827 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
Conclusion: The majority of children with RB in Uganda present clinically with leucokoria, and their parents or guardians seek medical intervention at a later stage. Moreover, there was a noticeably significant lag period for the patients to begin treatment after the diagnosis was done. PMID: 31316824 [PubMed]
Source: Journal of Ophthalmology - Category: Opthalmology Tags: J Ophthalmol Source Type: research
Authors: Lorenzo-González M, Torres-Durán M, Barbosa-Lorenzo R, Provencio-Pulla M, Barros-Dios JM, Ruano-Ravina A Abstract Introduction: Lung cancer is the most important cause of cancer mortality. It is a multifactorial disease with multiple risk factors, including residential radon exposure. Areas covered: The aim of this paper was to review the epidemiology of residential radon exposure and its impact on lung cancer risk. While tobacco is the main risk factor of lung cancer, residential radon is the first cause in never-smokers and the second in ever-smokers. Moreover, the synergistic effect betwee...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
Journal Name: Journal of Perinatal Medicine Issue: Ahead of print
Source: Journal of Perinatal Medicine - Category: Perinatology & Neonatology Source Type: research
Authors: Grossmann M, Ramchand SK, Milat F, Vincent A, Lim E, Kotowicz MA, Hicks J, Teede HJ Abstract INTRODUCTION: Representatives appointed by relevant Australian medical societies used a systematic approach for adaptation of guidelines (ADAPTE) to formulate clinical consensus recommendations on assessment and management of bone health in women with oestrogen receptor-positive early breast cancer receiving endocrine therapy. The current evidence suggests that women receiving adjuvant aromatase inhibitors and pre-menopausal woman treated with tamoxifen have accelerated bone loss and that women receiving adjuvant a...
Source: Medical Journal of Australia - Category: General Medicine Tags: Med J Aust Source Type: research
Publication date: Available online 18 July 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Karolina Rogala-Koziarska, Łukasz Samluk, Katarzyna A. NałęczAbstractPlasma membrane transporter SLC6A14 transports all neutral and basic amino acids in a Na/Cl – dependent way and it is up-regulated in many types of cancer. Mass spectrometry analysis of overexpressed SLC6A14–associated proteins identified, among others, the presence of cytosolic heat shock proteins (HSPs) and co-chaperones. We detected co-localization of overexpressed and native SLC6A14 with HSP90-beta and HSP70 (HS...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - Category: Molecular Biology Source Type: research
In this study, we investigated the effects of stress on immunosurveillance against cancer cells using a previously established examination stress model. We showed that the cancer killing activity (CKA) of granulocytes (also known as polymorphic nuclear cells, PMNs) is sharply reduced during examination stress stimulation in some donors who are psychologically sensitive to examination stress, with the concentration of plasma stress hormones (cortisone, epinephrine, and norepinephrine) increasing accordingly. The effects of stress hormones on immune cell CKA were also investigated under two in vitro co-incubation conditions,...
Source: Stress - Category: Research Tags: Stress Source Type: research
Publication date: 1 September 2019Source: Life Sciences, Volume 232Author(s): Meng Wang, Haibin Wu, Mingyue Duan, Ying Yang, Guoxia Wang, Fengyu Che, Bailing Liu, Wei He, Qiao Li, Liyu ZhangAbstractAimsCD123 represents an important acute myeloid leukemia (AML) therapeutic target. CD123 aptamers may potentially serve as tumor-homing ligands with excellent affinity and specificity for AML targeted therapy, but their complexity, laborious preparation and nuclease digestion limited pharmacological application. The aim of this study was to develop the first CD123 thioaptamer to overcome these obstacles.Main methodsFlow cytometr...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 18 July 2019Source: Journal of Environmental Chemical EngineeringAuthor(s): Keshaw R. Aadil, Neha Pandey, Solange I. Mussatto, Harit JhaAbstractThe present study uncovers the in-vitro cytotoxicity, sensing properties, catalytic and antibacterial activity of lignin functionalized silver nanoparticles (AGNPs). Fabricated AGNPs were characterized using UV-visible spectroscopy, particle size, X-ray diffraction (XRD) and Transmission Electron Microscopic (TEM) analyses. The typical surface plasmon resonance peak of AGNP was recorded at 410 nm, as confirmed from UV-visible spectrum. Synt...
Source: Journal of Environmental Chemical Engineering - Category: Chemistry Source Type: research
Publication date: Available online 18 July 2019Source: Chinese Chemical LettersAuthor(s): Lingzhi Ma, Tianfeng Yang, Zeyuan Zhang, Siping Yin, Zhongxiao Song, Wen Shi, Dake Chu, Yanmin Zhang, Mingming ZhangAbstractIn this work, a near-infrared emissive dipyridyl ligand was synthesized and used to prepare three platinum(II) metallacycles with different shapes via metal-coordination-driven self-assembly with different platinum(II) precursors. These metallacycles were further used for both cell imaging and cancer therapy, offering a new type of theranostic agents towards cancer treatment.Graphical Abstract
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
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