A phase 1 clinical trial of sequential pralatrexate followed by a 48‐hour infusion of 5‐fluorouracil given every other week in adult patients with solid tumors

CONCLUSIONSThe recommended dose of PDX was 148 mg/m2. A subset of heavily pretreated patients had PFS durations of ≥6 months with this regimen. Cancer 2015. © 2015 American Cancer Society.
Source: Cancer - Category: Cancer & Oncology Authors: Tags: Original Article Source Type: research

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We report the case of a 37-year-old female patient, without past medical history, with multicystic lung disease in a context of chronic abdominal pain, fatigue and weight loss. After several months of diagnostic delay, pathological examination of surgical lung biopsies led to the diagnosis of secondary deposits of pancreatic cancer. The clinical and radiogical situation deteriorated quickly with the development of alveolar consolidation and Aspergillus superinfection was then diagnosed. This case illustrates the value of an early decision to undertake surgical lung biopsy in the work-up of multicystic lung disease when can...
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
Publication date: Available online 25 June 2019Source: MethodsAuthor(s): Tejaswini Mallavarapu, Jie Hao, Youngsoon Kim, Jung Hun Oh, Mingon KangAbstractCancer is a genetic disease comprising multiple subtypes that have distinct molecular characteristics and clinical features. Cancer subtyping helps in improving personalized treatment and making decision, as different cancer subtypes respond differently to the treatment. The increasing availability of cancer related genomic data provides the opportunity to identify molecular subtypes. Several unsupervised machine learning techniques have been applied on molecular data of th...
Source: Methods - Category: Molecular Biology Source Type: research
Publication date: Available online 24 June 2019Source: Saudi Journal of Biological SciencesAuthor(s): Manal Abudawood, Hajera Tabassum, Mir Naiman Ali, Basmah Almaarik, Mohrah Alshaikh, Anas Dhaifallah AlGhamdi, Johara Yahya AlFaifi, Khalil Ibrahim Softa, Samia Sobki, Ali AljohiAbstractType 2 Diabetes Mellitus (T2DM) is the most widely known type of disorder of the endocrine system marked by hyperglycemia resulting either due to deficiency of insulin and or resistance. Persistent hyperglycemia induces oxidative stress and is suggested to play a prominent role in the pathophysiology underlying T2DM. Besides, oxidative stres...
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
Publication date: Available online 25 June 2019Source: Life SciencesAuthor(s): Mehdi Derakhshani, Hossein Abbaszadeh, Ali Akbar Movassaghpour, Amir Mehdizadeh, Majid Ebrahimi-Warkiani, Mehdi YousefiAbstractHematopoietic stem cells (HSCs) are a rare cell population in adult bone marrow, mobilized peripheral blood, and umbilical cord blood possessing self-renewal and differentiation capability into a full spectrum of blood cells. Bone marrow HSC transplantation has been considered as an ideal option for certain disorders treatment including hematologic diseases, leukemia, immunodeficiency, bone marrow failure syndrome, genet...
Source: Life Sciences - Category: Biology Source Type: research
This study identified the activation of Sirt3 played an important role in increasing sensitivity of ovarian cancer cells to cisplatin induced by ABT737. Furthermore, Sirt3 might represent a potential therapeutic target for ovarian cancer.
Source: Life Sciences - Category: Biology Source Type: research
CONCLUSIONS: Female medical students showed low knowledge of HPV vaccination and an extremely low HPV vaccination rate, but a higher level of HPV-related cervical cancer awareness. A substantial number of students were not yet sexually active or had never had sex without a condom. HPV vaccination is thus still important for our respondents. There is an emerging need in educational programs for students starting from their first semester of the program and for a broader informational campaign focused on schoolchildren and their parents. PMID: 31233171 [PubMed - in process]
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - Category: Dermatology Tags: Acta Dermatovenerol Alp Pannonica Adriat Source Type: research
CONCLUSIONS: This study argues for a local protective effect of cutis rhomboidalis nuchae against other ultraviolet light-induced cutaneous pathologies. PMID: 31233166 [PubMed - in process]
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - Category: Dermatology Tags: Acta Dermatovenerol Alp Pannonica Adriat Source Type: research
Publication date: Available online 24 June 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Yasmeena Jan, Muneeb Malik, Mifftha Yaseen, Sayeed Ahmad, Mohammed Imran, Suhail Rasool, Afrozul HaqAbstractIndia is a densely populated country known for its traditional, cultural and lingual diversity. In India Deficiency of vitamin D is seen in both the genders and among all the age groups. Micronutrient deficiencies are steadily adding to the increasing burden of health related co-morbidities with low dietary calcium and magnesium intake in Indian population. Despite lots of sunshine, vitamin D ins...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Publication date: Available online 24 June 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): I.P. Grabovec, S.V. Smolskaya, A.V. Baranovsky, V.N. Zhabinskii, Y.V. Dichenko, P.S. Shabunya, S.A. Usanov, N.V. StrushkevichAbstractOxysterols are derivatives of cholesterol and biologically active molecules that are involved in a number of functions, including cholesterol homeostasis, immune response, embryogenic development and pathophysiology of neurodegenerative diseases. Enzymes catalyzing their synthesis and metabolism are of particular interest as potential or evaluated drug targets. Here we re...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Publication date: 1 September 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 181Author(s): Guilin Cheng, Xiaomin Zhang, Yidan Chen, Robert J. Lee, Jiangfeng Wang, Ju Yao, Yingxin Zhang, Cheng Zhang, Kaifeng Wang, Bo YuAbstractBiodegradable polymeric nanoparticles (NPs) have been used frequently as nanocarriers for anticancer drugs. Linoleic acid conjugated SN38 (LA-SN38)-loaded NPs (EBNPs) were developed using biodegradable poly (ethylene oxide)-poly (butylene oxide) (PEO-PBO) diblock copolymer by titration hydration method without using a toxic organic solvent. The EBNPs had high drug loading efficiency and en...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
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