Ferrostatin-1 specifically targets mitochondrial iron-sulfur clusters and aconitase to improve cardiac function in Sirtuin 3 cardiomyocyte knockout mice

In this study, we tested whether the knockout of SIRT3 in cardiomyocytes (SIRT3cKO) promotes mitochondrial ferroptosis and whether the blockade of ferroptosis would ameliorate mitochondrial dysfunction.

Source: Journal of Molecular and Cellular Cardiology - May 9, 2024 Category: Cytology Authors: Aubrey C. Cantrell, Jessie Besanson, Quinesha Williams, Ngoc Hoang, Kristin Edwards, G. Reid Bishop, Yingjie Chen, Heng Zeng, Jian-Xiong Chen Source Type: research