Duodenal quantitative mucosal morphometry in children with environmental enteric dysfunction: a cross-sectional multi-country analysis

CONCLUSIONS: Morphometric analysis of duodenal biopsy slides across geographies identified morphologic features of EED, specifically short villi, elongated crypts, and a smaller V:C ratio relative to NPA slides; although not as severe as in celiac slides. Morphometry did not explain other EED features, suggesting that EED histopathologic processes may be operating independently of morphology. While acknowledging the challenges with obtaining relevant tissue, these data form the basis for further assessments of the role of morphometry in EED.PMID:38685382 | DOI:10.1016/j.ajcnut.2024.04.027

Source: The American Journal of Clinical Nutrition - April 30, 2024 Category: Nutrition Authors: Lubaina Ehsan David Coomes Paul Kelly Adam R Greene S Asad Ali Chola Mulenga Donna M Denno Kelley VanBuskirk Muhammad Faraz Raghib Mustafa Mahfuz Sean R Moore M Shabab Hossain Tahmeed Ahmed Peter B Sullivan Christopher A Moskaluk Sana Syed EEDBI Consortiu Source Type: research