Effects of salinity on behavior and reproductive toxicity of BPA in adult marine medaka

In this study, we exposed marine medaka (Oryzias melastigma) to BPA at different salinities (0 psμ, 15 psμ, and 30 psμ) for 70days to investigate the toxic effects. At 0 psμ salinity, BPA had an inhibitory effect on the swimming behavior of female medaka. At 15 psμ salinity, exposure to BPA resulted in necrotic cells in the ovaries but not on the spermatozoa. In addition, BPA exposure changed the transcript levels of genes related to the nervous system (gap43, elavl3, gfap, mbpa, and α-tubulin) and the hypothalamic-pituitary-gonadal (HPG) axis (fshr, lhr, star, arα, cyp11a, cyp17a1, cyp19a, and erα); the expression changes differed among salinity levels. These results suggest that salinity influences the adverse effects of BPA on the nervous system and reproductive system of medaka. These results emphasize the importance of considering the impact of environmental factors when carrying out ecological risk assessment of pollutants.PMID:38653400 | DOI:10.1016/j.chemosphere.2024.142103
Source: Chemosphere - Category: Chemistry Authors: Source Type: research