Neopterin in patients with COPD, asthma, and ACO: association with endothelial and lung functions

CONCLUSION: NP was related to disease severity of chronic airway diseases and involved in the pathogenesis of endothelial dysfunction. A high NP level may contribute to endothelial dysfunction by increasing the oxidative stress of ECs dose-dependently in a hypoxic environment. Our findings may provide a novel evaluation and therapeutic target for endothelial dysfunction related to chronic airway diseases.PMID:38637774 | PMC:PMC11027266 | DOI:10.1186/s12931-024-02784-4

Source: Respiratory Care - April 18, 2024 Category: Respiratory Medicine Authors: Yangli Liu Fengjia Chen Zhimin Zeng Chengcheng Lei Dubo Chen Xiaoyu Zhang Source Type: research