Conjugation of sulpiride with a cell penetrating peptide to augment the antidepressant efficacy and reduce serum prolactin levels

In conclusion, VPALR-SUL exhibited potential for enhancing sulpiride transport across the BBB, augmenting its antidepressant effects, and reducing serum prolactin levels. This study laid a foundation for improving sulpiride delivery and developing novel antidepressants.PMID:38642503 | DOI:10.1016/j.biopha.2024.116610

Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 20, 2024 Category: Drugs & Pharmacology Authors: Yuan Liang Yu Yang Ruiyan Huang Jiangyue Ning Xingyan Bao Zelong Yan Haotian Chen Li Ding Chang Shu Source Type: research