In silico design of a novel multi-epitope vaccine against HCV infection through immunoinformatics approaches

This study is the first to present this epitopes-adjuvant combination. The vaccine had acceptable physicochemical characteristics. The vaccine's 3D structure was predicted and validated. The vaccine's binding stability with Toll-like receptor 2 (TLR2) and TLR4 was confirmed using molecular docking and molecular dynamics (MD) simulation. The immune simulation revealed the vaccine's efficacy by increasing the population of B and T cells in response to vaccination. In silico expression in Escherichia coli (E. coli) was also successful.PMID:38621559 | DOI:10.1016/j.ijbiomac.2024.131517

Source: International Journal of Biological Macromolecules - April 15, 2024 Category: Biochemistry Authors: Sajjad Ahmad Fatemeh Mobini Demneh Bushra Rehman Taghreed N Almanaa Nahid Akhtar Hamidreza Pazoki-Toroudi Ali Shojaeian Mahdi Ghatrehsamani Samira Sanami Source Type: research