Effects of PDE-3 inhibition in persistent post-traumatic headache: evidence of cAMP-dependent signaling

ConclusionsOur results provide novel evidence showing that PDE-3 inhibition can elicit migraine-like headache in persons with PPTH. Given that PDE-3 inhibition increases intracellular cAMP levels, our findings allude to the potential therapeutic value of targeting cAMP-dependent signaling pathways in the management of PPTH. Further investigations are imperative to substantiate these insights and delineate the importance of cAMP-dependent signaling pathways in the neurobiologic mechanisms underlying PPTH.ClinicalTrials.gov IdentifierNCT05595993.
Source: The Journal of Headache and Pain - Category: Neurology Source Type: research