Extracellular acidification reveals the antiarrhythmic properties of amiodarone related to late sodium current-induced atrial arrhythmia

CONCLUSION: The pharmacological properties of AMIO concerning healthy rat atrial tissue are not dependent on pHe. However, the prevention of arrhythmias induced by INa-Late is pHe-dependent. The development of drugs analogous to AMIO with charge stabilization may help to create more effective drugs to treat arrhythmias related to the INa-Late.PMID:38619735 | DOI:10.1007/s43440-024-00597-2

Source: Pharmacological Reports - April 15, 2024 Category: Drugs & Pharmacology Authors: Michael Ramon de Lima Concei ção Jorge Lucas Teixeira-Fonseca Leisiane Pereira Marques Diego Santos Souza Fabiana da Silva Alc ântara Diego Jose Belato Orts Danilo Roman-Campos Source Type: research