Uveal melanoma cell lines Mel270 and 92.1 exhibit a mesenchymal phenotype and sensitivity to the cytostatic effects of transforming growth factor beta in vitro

CONCLUSIONS: Our findings indicate that UM cells are sensitive to the two arms of TGF-β signaling, which suggests that targeting the TGF-β pathway could be challenging in UM and would require a precise selection of patients in which only the prometastatic arm of TGF-β is activated.PMID:38601020 | PMC:PMC11006005

Source: Molecular Vision - April 11, 2024 Category: Molecular Biology Authors: Coralie Doudnikoff Delphine Leclerc Ga ëlle Angenard David Gilot C édric Coulouarn Frederic Mouriaux Source Type: research