Cancers, Vol. 16, Pages 1501: Contemporary Approaches to the Surgical Management of Pancreatic Neuroendocrine Tumors
Cancers, Vol. 16, Pages 1501: Contemporary Approaches to the Surgical Management of Pancreatic Neuroendocrine Tumors
Cancers doi: 10.3390/cancers16081501
Authors:
Akash Kartik
Valerie L. Armstrong
Chee-Chee Stucky
Nabil Wasif
Zhi Ven Fong
The incidence of pancreatic neuroendocrine tumors (PNETs) is on the rise primarily due to the increasing use of cross-sectional imaging. Most of these incidentally detected lesions are non-functional PNETs with a small proportion of lesions being hormone-secreting, functional neoplasms. With recent advances in surgical approaches and systemic therapies, the management of PNETs have undergone a paradigm shift towards a more individualized approach. In this manuscript, we review the histologic classification and diagnostic approaches to both functional and non-functional PNETs. Additionally, we detail multidisciplinary approaches and surgical considerations tailored to the tumor’s biology, location, and functionality based on recent evidence. We also discuss the complexities of metastatic disease, exploring liver-directed therapies and the evolving landscape of minimally invasive surgical techniques.
Source: Cancers - Category: Cancer & Oncology Authors: Akash Kartik Valerie L. Armstrong Chee-Chee Stucky Nabil Wasif Zhi Ven Fong Tags: Review Source Type: research
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