Cancers, Vol. 16, Pages 1501: Contemporary Approaches to the Surgical Management of Pancreatic Neuroendocrine Tumors

Cancers, Vol. 16, Pages 1501: Contemporary Approaches to the Surgical Management of Pancreatic Neuroendocrine Tumors Cancers doi: 10.3390/cancers16081501 Authors: Akash Kartik Valerie L. Armstrong Chee-Chee Stucky Nabil Wasif Zhi Ven Fong The incidence of pancreatic neuroendocrine tumors (PNETs) is on the rise primarily due to the increasing use of cross-sectional imaging. Most of these incidentally detected lesions are non-functional PNETs with a small proportion of lesions being hormone-secreting, functional neoplasms. With recent advances in surgical approaches and systemic therapies, the management of PNETs have undergone a paradigm shift towards a more individualized approach. In this manuscript, we review the histologic classification and diagnostic approaches to both functional and non-functional PNETs. Additionally, we detail multidisciplinary approaches and surgical considerations tailored to the tumor’s biology, location, and functionality based on recent evidence. We also discuss the complexities of metastatic disease, exploring liver-directed therapies and the evolving landscape of minimally invasive surgical techniques.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research