StarD5 levels of expression correlate with onset and progression of steatosis and liver fibrosis

CONCLUSIONS: StarD5's downregulation with hepatic lipid excess is a previously unappreciated physiologic function appearing to promote lipid storage for future needs. Conversely, StarD5's lingering downregulation with prolonged lipid/cholesterol excess accelerates fatty liver's transition to fibrosis; mediated via dysregulation in the oxysterol signaling pathway.PMID:38591148 | DOI:10.1152/ajpgi.00024.2024

Source: Am J Physiol Gastroi... - April 9, 2024 Category: Gastroenterology Authors: Genta Kakiyama Kei Minowa Nanah Bai-Kamara Taishi Hashiguchi William M Pandak Daniel Rodriguez-Agudo Source Type: research