Deep-targeted gene sequencing reveals ARID1A mutation as an important driver of glioblastoma

CONCLUSION: The ARID1A gene is a critical predictive biomarker for glioma. Mutations at the ARID1A locus alter the stability of the SWI/SNF complex, leading to changes in transcriptional regulation in glioma cells. This contributes to an increased malignant phenotype of GBM and plays a pivotal role in mediating chemoresistance.PMID:38600891 | DOI:10.1111/cns.14698

Source: CNS Neuroscience and Therapeutics - April 11, 2024 Category: Neuroscience Authors: Menglin Xiao Xiaoteng Cui Can Xu Lei Xin Jixing Zhao Shixue Yang Biao Hong Yanli Tan Jie Zhang Xiang Li Jie Li Chunsheng Kang Chuan Fang Source Type: research