Comparison of propofol pharmacokinetic and pharmacodynamic models for awake craniotomy: A prospective observational study

CONCLUSION: When using the ‘asleep-awake-asleep’ anaesthetic technique during awake craniotomy, we advocate using the PK/PD model proposed by Schnider. Due to considerable interindividual variation, additional monitoring of anaesthetic depth is recommended. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT 01128465.
Source: European Journal of Anaesthesiology - Category: Anesthesiology Tags: Pharmacology Source Type: research