Ex Vivo Lung Perfusion as a Novel Model System of the Lung Resident Humoral Immune Response to Influenza

Purpose: Murine studies showthat flu-specific B cells in lung exhibit differential fates, migration properties and plasma cell differentiation potential as early as 24 hours after infection, underscoring the importance of studying the properties of flu-specific B cells recalled to human lung over time after infection. Ex vivo lung perfusion (EVLP) is a clinical bridge to transplant modality that maintains human lung viable over time. We hypothesized that EVLP can be adapted to facilitate dynamic studies of the humoral immune response to influenza that is recalled to the human lung longitudinally after infection
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research