Metformin Inhibits Zika Virus Infection in Trophoblast Cell Line

In this study, we evaluated metformin treatment during ZIKV infection in vitro in a JEG3-permissive trophoblast cell line. Our results demonstrate that metformin affects viral replication and protein synthesis and reverses cytoskeletal changes promoted by ZIKV infection. In addition, it reduces lipid droplet formation, which is associated with lipogenic activation of infection. Taken together, our results indicate that metformin has potential as an antiviral agent against ZIKV infection in vitro in trophoblast cells.PMID:38592489 | DOI:10.1007/s00284-024-03651-7

Source: Current Microbiology - April 9, 2024 Category: Microbiology Authors: Manuel Adr ían Velazquez-Cervantes Orestes L ópez-Ortega Victor Javier Cruz-Holgu ín Luis Herrera Moro-Huitron Arturo Flores-Pliego Ignacio Lara-Hernandez Mauricio Comas-Garc ía Oscar Villavicencio-Carrisoza Addy Cecilia Helguera-Reppeto Haruki Ar év Source Type: research