RSV-GenoScan: an automated pipeline for whole-genome human respiratory syncytial virus (RSV) sequence analysis

We present RSV-GenoScan, a fast and easy-to-use pipeline for WGS analysis of RSV generated by HTS on Illumina or Nanopore platforms. RSV-GenoScan automates the WGS analysis steps directly from the raw sequence data. The pipeline filters the sequence data, maps the reads to the RSV reference genome, generates a consensus sequence, identifies the RSV subgroup, and lists amino acid mutations, insertions and deletions in the F and G viral genes. This enables the rapid identification of mutations in these coding genes that are known to confer resistance to monoclonal antibodies.AVAILABILITY: RSV-GenoScan is freely available at https://github.com/AlexandreD-bio/RSV-GenoScan.PMID:38588779 | DOI:10.1016/j.jviromet.2024.114938
Source: Journal of Virological Methods - Category: Virology Authors: Source Type: research