Deletion of Luzp2 Does Not Cause Hearing Loss in Mice

AbstractDeafness is the prevailing sensory impairment among humans, impacting every aspect of one's existence. Half of congenital deafness cases are attributed to genetic factors. Studies have shown thatLuzp2 is expressed in hair cells (HCs) and supporting cells of the inner ear, but its specific role in hearing remains unclear. To determine the importance ofLuzp2 in auditory function, we generated mice deficient inLuzp2. Our results revealed thatLuzp2 has predominant expression within the HCs and pillar cells. However, the loss ofLuzp2 did not result in any changes in auditory threshold. HCs or synapse number and HC stereocilia morphology inLuzp2 knockout mice did not show any notable distinctions. This was the first study of the role ofLuzp2 in hearing in mice, and our results provide important guidance for the screening of deafness genes.
Source: Neuroscience Bulletin - Category: Neuroscience Source Type: research