Novel clinical phenotypes, drug categorization, and outcome prediction in drug-induced cholestasis: Analysis of a database of 432 patients developed by literature review and machine learning support

CONCLUSIONS: We identified novel associations among DIC manifestations and disclosed novel DIC subphenotypes with specific clinical and chemical traits. The developed predictive DIC outcome model could facilitate DIC prognosis in clinical practice and drug categorization.PMID:38574623 | DOI:10.1016/j.biopha.2024.116530

Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 4, 2024 Category: Drugs & Pharmacology Authors: Marta Moreno-Torres Ernesto L ópez-Pascual Anna Rapisarda Guillermo Quint ás Annika Drees Inger-Lise Steffensen Thomas Luechtefeld Eva Serrano-Candelas Marina Garcia de Lomana Domenico Gadaleta Hubert Dirven Mathieu Vinken Ramiro Jover Source Type: research