A Survey of MicroRNAs Shown to be Relevant to Muscle Aging

RNA molecules are produced in the cell nucleus by transcription machinery that reads gene sequences from the genome. MicroRNAs are among the varieties of RNA molecule that are not translated by a ribosome to produce proteins. Instead they directly participate in cell functions, often by altering the expression of other genes. Many microRNAs appear to be important players in the regulation of specific cell behaviors and tissue functions, such as regeneration and maintenance of tissues. In today's open access paper, the authors provide an overview of some of the microRNAs that have been identified as important or potentially interesting in the context of the aging of muscle tissue, particularly in the decline of maintenance and regeneration. In the broader context beyond muscle tissue, a few first therapies that target specific microRNAs are making their way towards the clinic, primarily to treat forms of cancer. A broader range of such therapies is a possibility for the years ahead, including those aimed at restored muscle function in later life. The role of non-coding RNAs in muscle aging: regulatory mechanisms and therapeutic potential Non-coding RNAs (ncRNAs) are a varied family of RNA that do not code for proteins but are crucial for many biological activities, including gene regulation, epigenetic modifications, and chromatin remodeling. This class of RNAs includes microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and oth...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs