Rakicidin J and K, two cytotoxic and antibacterial cyclic depsipeptides from the marine bacterium < em > Micromonospora chalcea < /em >

Nat Prod Res. 2024 Apr 3:1-7. doi: 10.1080/14786419.2024.2335354. Online ahead of print.ABSTRACTRakicidin J (1) and rakicidin K (2), two new cyclic depsipeptides, were isolated from culture broth of Micromonospora chalcea FIM-R150103. Their structures were elucidated by extensive analysis of NMR, HR-ESI-MS, and electronic circular dichroism (ECD) data. The two compounds showed strong cytotoxic activity against human colon carcinoma HCT-8 and human pancreatic cancer PANC-1 cells under normoxic and hypoxic conditions in the range of IC50 values from 0.024 to 0.79 μg/mL. Moreover, compounds 1 and 2 also showed moderate antibacterial activity against ten Gram-positive bacterial strains with MIC values ranging from 4 to more than 32 μg/mL. Structure-activity relationship of these two compounds with a close analogue, rakicidin B1, is also discussed.PMID:38571336 | DOI:10.1080/14786419.2024.2335354
Source: Natural Product Research - Category: Biochemistry Authors: Source Type: research