Single-Cell RNA Sequencing Reveals Repair Features of Human Umbilical Cord Mesenchymal Stromal Cells

CONCLUSIONS: UC-MSCs with a progenitor-like transcriptome, but not with a fibroblast-like transcriptome, provide lung protection in experimental BPD. High expression of major histocompatibility complex class I is associated with reduced therapeutic benefit. scRNA-seq may be useful to identify subsets of MSCs with superior repair capacity for clinical application.PMID:38564376 | DOI:10.1164/rccm.202310-1975OC

Source: Respiratory Care - April 2, 2024 Category: Respiratory Medicine Authors: Chan èle Cyr-Depauw David P Cook Ivana Mi žik Flore Lesage Arul Vadivel Laurent Renesme Yupu Deng Shumei Zhong Pauline Bardin Liqun Xu Marius A M öbius Jenny Marzahn Daniel Freund Duncan J Stewart Barbara C Vanderhyden Mario R üdiger Bernard Th ébaud Source Type: research