Huanglian Jiedu decoction inhibits vascular smooth muscle cell-derived foam cell formation by activating autophagy via suppressing P2RY12

CONCLUSIONS: HLJDD inhibited AS in vivo and foam cell formation in vitro by restoring P2RY12/PI3K/AKT signaling pathway-suppressed autophagy. This study is the first to reveal an interaction between P2RY12 and PI3K3CB.PMID:38561055 | DOI:10.1016/j.jep.2024.118125

Source: Atherosclerosis - April 1, 2024 Category: Cardiology Authors: Jinhai Lin Mingyang Gu Xiaolong Wang Yuanyuan Chen Nhi Van Chau Junlong Li Qingmin Chu Lijin Qing Wei Wu Source Type: research