One-pot synthesis, structural investigation, antitumor activity and molecular docking approach of two decavanadate compounds

In this study, the cytotoxic and the anti-proliferative activities of compounds (1) and (2) on human cancer cells (U87 and MDA-MB-231) were investigated. Both compounds demonstrated dose-dependent anti-proliferative activity on U87 and MDA-MB-231 with respective IC50 values of 0.82 and 0.31 μM and 1.4 and 1.75 μM. These data provide evidence on the potential anticancer activity of [(C6H13N4)2][Mg(H2O)6]2[O28V10].6H2O and [(C7H11N2)4][Mg(H2O)2][O28V10].4H2O. Molecular docking of the compounds was also examined. Molecular docking studies were performed for both compounds against four target receptors and revealed better binding affinity with these targets in comparison to Cisplatin. Moreover, molecular docking investigations suggest that these compounds may function as potential inhibitors of proteins in brain and breast cells, exhibiting greater efficiency compared to Cisplatin.PMID:38547784 | DOI:10.1016/j.jinorgbio.2024.112533

Source: Journal of Inorganic Biochemistry - March 28, 2024 Category: Biochemistry Authors: Rihab Dridi Zaineb Abdelkafi-Koubaa Najet Srairi-Abid Bhavesh Socha Mohamed Faouzi Zid Source Type: research