Targeting TRP channels for pain relief: A review of current evidence from bench to bedside

Curr Opin Pharmacol. 2024 Apr;75:102447. doi: 10.1016/j.coph.2024.102447. Epub 2024 Mar 11.ABSTRACTSeveral decades of research support the involvement of transient receptor potential (TRP) channels in nociception. Despite the disappointments of early TRPV1 antagonist programs, the TRP family remains a promising therapeutic target in pain disorders. High-dose capsaicin patches are already in clinical use to relieve neuropathic pain. At present, localized injections of the side-directed TRPV1 agonist capsaicin and resiniferatoxin are undergoing clinical trials in patients with osteoarthritis and bone cancer pain. TRPA1, TRPM3, and TRPC5 channels are also of significant interest. This review discusses the role of TRP channels in human pain conditions.PMID:38471384 | DOI:10.1016/j.coph.2024.102447
Source: Current Opinion in Pharmacology - Category: Drugs & Pharmacology Authors: Source Type: research