Viruses, Vol. 16, Pages 545: Fluoxetine and Sertraline Potently Neutralize the Replication of Distinct SARS-CoV-2 Variants
Viruses, Vol. 16, Pages 545: Fluoxetine and Sertraline Potently Neutralize the Replication of Distinct SARS-CoV-2 Variants
Viruses doi: 10.3390/v16040545
Authors:
Laura Thümmler
Nadine Beckmann
Carolin Sehl
Matthias Soddemann
Peer Braß
Maren Bormann
Leonie Brochhagen
Carina Elsner
Nicolas Hoertel
Céline Cougoule
Sandra Ciesek
Marek Widera
Ulf Dittmer
Monika Lindemann
Peter A. Horn
Oliver Witzke
Stephanie Kadow
Markus Kamler
Erich Gulbins
Katrin Anne Becker
Adalbert Krawczyk
The pandemic caused by SARS-CoV-2 is still a major health problem. Newly emerging variants and long-COVID-19 represent a challenge for the global health system. In particular, individuals in developing countries with insufficient health care need easily accessible, affordable and effective treatments of COVID-19. Previous studies have demonstrated the efficacy of functional inhibitors of acid sphingomyelinase against infections with various viruses, including early variants of SARS-CoV-2. This work investigated whether the acid sphingomyelinase inhibitors fluoxetine and sertraline, usually used as antidepressant molecules in clinical practice, can inhibit the replication of the former and recently emerged SARS-CoV-2 variants in vitro. Fluoxetine and sertraline potently inhibited the infection with pseudotyped virus-like particles and SARS-CoV-2 variants D614G, alpha, delta, omicron BA.1 and omicron BA.5. These results highlight fluoxetine and sertraline as...
Source: Viruses - Category: Virology Authors: Laura Th ümmler Nadine Beckmann Carolin Sehl Matthias Soddemann Peer Bra ß Maren Bormann Leonie Brochhagen Carina Elsner Nicolas Hoertel C éline Cougoule Sandra Ciesek Marek Widera Ulf Dittmer Monika Lindemann Peter A. Horn Oliver Witzke Stephanie Kado Tags: Article Source Type: research
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