Amyloid pathology mediates the associations between plasma fibrinogen and cognition in non ‐demented adults

The current study aimed to comprehensively examine the interrelationships of fibrinogen, cognitive decline, and cerebrospinal fluid Alzheimer's disease biomarkers in non-demented individuals. Our findings were as follows: (1) Increased fibrinogen levels were associated with cognitive decline. (2) Increased fibrinogen levels were associated with A β pathology. (3) The impact of fibrinogen on cognition could be mediated by Aβ pathology. AbstractThough previous studies revealed the potential associations of elevated levels of plasma fibrinogen with dementia, there is still limited understanding regarding the influence of Alzheimer's disease (AD) biomarkers on these associations. We sought to investigate the interrelationships among fibrinogen, cerebrospinal fluid (CSF) AD biomarkers, and cognition in non-demented adults. We included 1996 non-demented adults from the Chinese Alzheimer's Biomarker and LifestylE (CABLE) study and 337 from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. The associations of fibrinogen with AD biomarkers and cognition were explored using multiple linear regression models. The mediation analyses with 10  000 bootstrapped iterations were conducted to explore the mediating effects of AD biomarkers on cognition. In addition, interaction analyses and subgroup analyses were conducted to assess the influence of covariates on the relationships between fibrinogen and AD biomarkers. Participants exhibitin g low Aβ42 were designated as A+, ...
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: ORIGINAL ARTICLE Source Type: research