Association between microsatellite status and characteristics and outcomes of early-onset compared to late-onset rectal cancer

ConclusionsIn both age groups, MSI-H rectal cancers were more often mucinous and poorly differentiated carcinomas and had pT3-4 stage more often than MSS cancers. MSI-H rectal cancers tend to present less often with distant metastases and nodal involvement than MSS cancers only in early-onset, but not in late-onset rectal cancers. The association between MSI status and survival was not notable in this study, whether in the early-onset or late-onset groups.
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research