PD-L1 Expression in Colorectal Carcinoma Correlates with the Immune Microenvironment

ConclusionsThe present study showed a relatively lower frequency of PD-L1 in CRC from the Eastern Indian cohort. The immune cell concentration in the present study was calculated using image analysis-based objectivised methods. Significant correlation of PD-L1 expression in tumor cells with the tumor-infiltrating immune cells indicated its crucial role in the pathobiology of CRC especially by regulating the TIME. Considering the therapeutic implication of PD-L1 in various malignancies, it may be one of the crucial therapeutic targets in a proportion of cases.
Source: Journal of Gastrointestinal Cancer - Category: Cancer & Oncology Source Type: research