Novel Angiogenesis Role of GLP-1(32-36) to Rescue Diabetic Ischemic Lower Limbs via GLP-1R-Dependent Glycolysis in Mice

CONCLUSIONS: Our study provides a novel mechanism with which GLP-1(32-36) acts in modulating metabolic reprogramming toward glycolytic flux in partnership with GLP-1R for improved angiogenesis in high glucose-exposed EPCs and T1DM murine models. We propose that GLP-1(32-36) could be used as a monotherapy or add-on therapy with existing treatments for peripheral artery disease.REGISTRATION: URL: www.ebi.ac.uk/metabolights/; Unique identifier: MTBLS9543.PMID:38511325 | DOI:10.1161/ATVBAHA.124.320714

Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 21, 2024 Category: Cardiology Authors: Yikai Zhang Shengyao Wang Qiao Zhou Yi Xie Yepeng Hu Weihuan Fang Changxin Yang Zhe Wang Shu Ye Xinyi Wang Chao Zheng Source Type: research