Population pharmacokinetic analyses of methotrexate in pediatric patients: a systematic review

ConclusionA more rigorous external evaluation needs to be performed before routine clinical use to select the appropriate PopPK model. Further research is necessary to incorporate larger cohorts or pool analyses in specific susceptible pediatric populations to improve the understanding of predicted exposure profiles and covariate identification.
Source: European Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Source Type: research