Rintatolimod in Advanced Pancreatic Cancer enhances Anti-Tumor Immunity through Dendritic Cell-Mediated T Cell Responses

CONCLUSIONS: This study presents compelling evidence of the immune-stimulatory properties linked to TLR-3 activation through rintatolimod. Rintatolimod may break immunological tolerance by enhancing anti-tumor immunity through DC-mediated Th-cell responses. Furthermore, our findings lay the groundwork for investigating the potential synergy between TLR-3 activation and immune checkpoint inhibitor therapy to improve therapeutic outcomes.PMID:38488815 | DOI:10.1158/1078-0432.CCR-23-4085

Source: Clinical Cancer Research - March 15, 2024 Category: Cancer & Oncology Authors: Casper W F van Eijck Hassana El Haddaoui Songul Kucukcelebi Disha Vadgama Amine Fellah Dana A M Mustafa Joachim G J V Aerts Casper H J van Eijck Marcella Willemsen Source Type: research