Systemic loss of CD36 aggravates NAFLD-related HCC through MEK1/2-ERK1/2 signaling pathway

CONCLUSION: Systemic loss of CD36 leaded to the advancement of NAFLD to HCC by causing lipid disorders and metabolic inflammation, a process that involves the activation of MAPK signaling pathway. We found that CD36 contributes significantly to the maintenance of metabolic homeostasis in NAFLD-HCC.PMID:38492244 | DOI:10.1016/j.bbrc.2024.149781

Source: Biochemical and Biophysical Research communications - March 16, 2024 Category: Biochemistry Authors: Enze Zheng Qianqian Chen Anhua Xiao Xiaoqing Luo Qiannan Lu Chuan Tian Huan Liu Jinqing Zhao Li Wei Ping Yang Yaxi Chen Source Type: research