Polystyrene microplastics impair the functions of cultured mouse Leydig (TM3) and Sertoli (TM4) cells by inducing mitochondrial-endoplasmic reticulum damage

This study is the first to elucidate the intracellular mechanism underlying the effects of PS-MPs in somatic testicular cells, corroborating that PS-MP might be one of the causes of an increase in male infertility through the impairment of steroidogenesis in Leydig cells and of the nurse function of Sertoli cells. Thus, our findings contributed with new information to the mechanism underlying the effects of PS-MP on the male reproductive system.PMID:38479314 | DOI:10.1016/j.ecoenv.2024.116202

Source: Ecotoxicology and Environmental Safety - March 13, 2024 Category: Environmental Health Authors: Giulia Grillo Sara Falvo Debora Latino Gabriella Chieffi Baccari Massimo Venditti Maria Maddalena Di Fiore Sergio Minucci Alessandra Santillo Source Type: research