Association between CFTR modulators and changes in iron deficiency markers in cystic fibrosis

Extrapulmonary manifestations are a major source of morbidity and poor quality of life for people with cystic fibrosis (pwCF), and include pancreatic exocrine and endocrine dysfunction, intestinal obstruction, chronic liver disease, reproductive dysfunction, and significant nutritional deficiencies [1,2]. Small, single center studies have reported that iron deficiency (ID) is a common extrapulmonary comorbidity in pwCF, with a reported prevalence of 40 –80 % [3–5]. The presence of ID increases with advancing age and has been associated with markers for poor outcomes, including shorter time to pulmonary exacerbations, lower lung function, and increased sputum Pseudomonas aeruginosa (PsA) [4–7].

Source: Journal of Cystic Fibrosis - March 14, 2024 Category: Respiratory Medicine Authors: Shijing Jia, Yizhuo Wang, Melissa H Ross, Jonathan B Zuckerman, Susan Murray, MeiLan K Han, Shannon E Cahalan, Blair E Lenhan, Ryan N Best, Jennifer L Taylor-Cousar, Richard H Simon, Linda J Fitzgerald, Jonathan P Troost, Suman L Sood, Alex H Gifford Tags: Original Article Source Type: research