ICG Functionalized Gold Nano Stars Allow for Delivery of Therapeutics and Deep Tumor Imaging Intraoperatively

The primary management of head and neck squamous cell carcinoma relies on complete surgical resection of the tumor, as positive margins are associated with decreased survival. The advantages of radiotherapeutic (RT) dose de-escalation and less aggressive treatments provide better patient quality of life, assuming complete tumor control can still be achieved. The use of gold nanostars (GNS) to accumulate in cancerous tissues via the enhanced permeability and retention (EPR) effect can be employed to localize and treat cancer, offering the potential for enhanced margin delineation and RT dose reduction while still maintaining tumor control.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: 214 Source Type: research